I. Litaba tsa Motheo
Lebitso la tlhaho: Semaglutide
Mofuta: GLP-1 receptor agonist (analoge ea nako e telele ea glucagon-joaloka peptide-1)
Mokhoa oa Tsamaiso: Ente e ka tlas'a letlalo (hang ka beke)
II. Lipontšo le Boemo ba Kamohelo ea Lehae
Lipontšo tse Amoheletsoeng
Kalafo ea Mofuta oa 2 oa Lefu la tsoekere (E amohetsoe ke NMPA):
Tekanyetso: 0.5 mg kapa 1.0 mg, hang ka beke.
Liketso: E laola tsoekere ea mali le ho fokotsa kotsi ea pelo.
Kalafo ya Botenya/Botenya
III. Mokhoa oa ho sebetsa le ho sebetsa hantle
Core Mechanism: E kenya tšebetsong li-receptor tsa GLP-1, e liehisa ho tsoa ka mpeng, 'me e eketsa ho khora.
E sebetsa setsing sa hypothalamic appetite, e thibela takatso ea lijo.
E ntlafatsa kutloisiso ea insulin mme e laola metabolism.
Katleho ea ho Fokotsa 'Mele (Ho ipapisitsoe le liteko tsa machaba tsa bongaka):
Karolelano ea tahlehelo ea boima ba 'mele ho feta libeke tse 68: 15% -20% (hammoho le mekhoa ea bophelo).
Bakuli ba se nang lefu la tsoekere (BMI ≥30 kapa ≥ 27 ba nang le mathata):
Bakuli ba nang le lefu la tsoekere: phello e fokolang ea boima ba 'mele (hoo e ka bang 5% -10%).
IV. Sebetsang Baahi le Contraindications
Tšebeliso ea Baahi
Maemo a Machabeng (sheba WHO):
BMI ≥30 (botenya);
BMI ≥ 27 ka khatello ea mali, lefu la tsoekere, kapa mafu a mang a metabolism (boima bo feteletseng).
Tloaelo ea Lapeng: E hloka tlhahlobo ea ngaka; hajoale e sebelisoa haholo ho laola boima ba 'mele ho bakuli ba nang le lefu la tsoekere.
Contraindications
Histori ea botho kapa ea lelapa ea medullary thyroid carcinoma (MTC);
Multiple endocrine neoplasia syndrome mofuta oa 2 (MEN2);
Basali ba bakhachane kapa ba anyesang;
Mafu a matla a ka mpeng (joalo ka nalane ea pancreatitis).
V. Liphello le Likotsi
Litla-morao tse tloaelehileng (ketsahalo> 10%):
Ho nyekeloa ke pelo, ho hlatsa, letšollo, pipitlelano (ho fokotsoa ka tšebeliso ea nako e telele).
Ho fokotseha ha takatso ea lijo, mokhathala.
Likotsi tse Tebileng:
Thyroid C-cell tumors (likotsi tse bontšitsoeng lithutong tsa liphoofolo, tse e-s'o hlake ho batho);
Pancreatitis, lefu la gallbladder;
Hypoglycemia (tlhokomelo e hlokahalang ha e sebelisoa hammoho le li-agents tse ling tsa hypoglycemic).
VI. Tšebeliso ea hona joale Chaena
Mekhoa ea ho Fumana:
Kalafo ea Lefu la Lefu la tsoekere: Lengolo la ngaka le tsoang sepetleleng se tloaelehileng.
Kalafo ea ho Fokotsa Boima: E hloka tlhahlobo e tiileng ke ngaka; mafapha a mang a lipetlele tsa thuto e phahameng ea endocrinology a ka e laela.
Likotsi Tse Tsoang Mecheng e sa Rekoang: Lithethefatsi tse rekoang ka mecha eo e seng ea molao e ka ’na ea e-ba tsa maiketsetso kapa tsa bolokoa ka tsela e sa lokelang, tsa baka likotsi tsa tšireletso.
VII. Litlhahiso tsa Tšebeliso
Latela Taelo ea Ngaka ka Thata: Sebelisa feela ka mor'a hore ngaka e hlahlobe matšoao a metabolic le nalane ea bongaka ea lelapa.
Mokhoa o Kopanetsoeng oa Bophelo: Meriana e hloka ho kopanngoa le taolo ea lijo le boikoetliso ho finyella liphello tse ntle.
Tlhokomelo ea Nako e Telele: Kamehla hlahloba tšebetso ea qoqotho, li-enzyme tsa pancreatic, le tšebetso ea sebete le liphio.
Nako ea poso: Nov-03-2025